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Effects of early-life stress on serotonin(1A) receptors in juvenile Rhesus monkeys measured by positron emission tomography.


ABSTRACT: BACKGROUND:Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin(1A) receptor (5-HT(1A)R) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders. METHODS:To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emission tomography to measure in vivo 5-HT(1A)R density and apparent dissociation constant (K(D)(app)) in the brain of juvenile Rhesus monkeys exposed to the early-life stress of peer-rearing. RESULTS:In general, 5-HT(1A)R density and K(D)(app) were decreased in peer-reared compared with control mother-reared animals. However, increase in receptor density was found in the dorsomedial prefrontal cortex of peer-reared females. CONCLUSIONS:These findings suggest that exposure to an adverse early-life environment during infancy is associated with long-term alterations in the serotonin system and support previous studies suggesting that reduced 5-HT(1A)R density during development might be a factor increasing vulnerability to stress-related neuropsychiatric disorders. Furthermore, alterations in the serotonin system seemed to be gender- and region-specific, providing a biological basis for the higher prevalence of affective disorders in women.

SUBMITTER: Spinelli S 

PROVIDER: S-EPMC2882499 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Effects of early-life stress on serotonin(1A) receptors in juvenile Rhesus monkeys measured by positron emission tomography.

Spinelli Simona S   Chefer Svetlana S   Carson Richard E RE   Jagoda Elaine E   Lang Lixin L   Heilig Markus M   Barr Christina S CS   Suomi Stephen J SJ   Higley J Dee JD   Stein Elliot A EA  

Biological psychiatry 20100220 12


<h4>Background</h4>Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin(1A) receptor (5-HT(1A)R) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders.<h4>Methods</h4>To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emissio  ...[more]

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