Ontology highlight
ABSTRACT:
SUBMITTER: Spinelli S
PROVIDER: S-EPMC2882499 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Spinelli Simona S Chefer Svetlana S Carson Richard E RE Jagoda Elaine E Lang Lixin L Heilig Markus M Barr Christina S CS Suomi Stephen J SJ Higley J Dee JD Stein Elliot A EA
Biological psychiatry 20100220 12
<h4>Background</h4>Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin(1A) receptor (5-HT(1A)R) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders.<h4>Methods</h4>To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emissio ...[more]