Effects of early-life stress on serotonin(1A) receptors in juvenile Rhesus monkeys measured by positron emission tomography.

ABSTRACT:

Background

Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin(1A) receptor (5-HT(1A)R) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders.

Methods

To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emission tomography to measure in vivo 5-HT(1A)R density and apparent dissociation constant (K(D)(app)) in the brain of juvenile Rhesus monkeys exposed to the early-life stress of peer-rearing.

Results

In general, 5-HT(1A)R density and K(D)(app) were decreased in peer-reared compared with control mo

SUBMITTER: Spinelli S 

PROVIDER: S-EPMC2882499 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature