Ontology highlight
ABSTRACT:
SUBMITTER: Rumpf C
PROVIDER: S-EPMC2883734 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Rumpf Cornelia C Cipak Lubos L Novatchkova Maria M Li Zhang Z Polakova Silvia S Dudas Andrej A Kovacikova Ines I Miadokova Eva E Ammerer Gustav G Gregan Juraj J
Cell cycle (Georgetown, Tex.) 20100515 9
Meiosis is the process which produces haploid gametes from diploid precursor cells. This reduction of chromosome number is achieved by two successive divisions. Whereas homologs segregate during meiosis I, sister chromatids segregate during meiosis II. To identify novel proteins required for proper segregation of chromosomes during meiosis, we applied a high-throughput knockout technique to delete 87 S. pombe genes whose expression is upregulated during meiosis and analyzed the mutant phenotypes ...[more]