Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC3464108 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Chen Zhiming Z McCrosky Scott S Guo Weichao W Li Hua H Gerton Jennifer L JL
G3 (Bethesda, Md.) 20121001 10
Cohesion, the force that holds sister chromatids together from the time of DNA replication until separation at the metaphase to anaphase transition, is mediated by the cohesin complex. This complex is also involved in DNA damage repair, chromosomes condensation, and gene regulation. To learn more about the cellular functions of cohesin, we conducted a genetic screen in Schizosaccharomyces pombe with two different cohesin mutants (eso1-G799D and mis4-242). We found synthetic negative interactions ...[more]