Ontology highlight
ABSTRACT:
SUBMITTER: Hervas-Aguilar A
PROVIDER: S-EPMC2884189 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Hervás-Aguilar América A Rodríguez-Galán Olga O Galindo Antonio A Abenza Juan F JF Arst Herbert N HN Peñalva Miguel A MA
Fungal genetics and biology : FG & B 20100401 7
ESCRT-III heteropolymers mediate membrane protein cargo sorting into multivesicular endosomes for subsequent vacuolar degradation. We studied the localization of largely uncharacterized Aspergillus nidulans ESCRT-III using its key structural component Vps32 and the 'associated' component DidB(Did2). Vps32-GFP localizes to motile early endosomes as reported, but predominates in aggregates often associated with vacuoles due to inability to dissociate from endosomes. DidB(Did)(2) regulating Vps4 (t ...[more]