Unknown

Dataset Information

0

CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.

ABSTRACT: Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).

SUBMITTER: Panayotopoulou EG 

PROVIDER: S-EPMC2884518 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.

Panayotopoulou Effrosini G EG   Sgouras Dionyssios N DN   Papadakos Konstantinos S KS   Petraki Kalliopi K   Breurec Sébastien S   Michopoulos Spyros S   Mantzaris Gerassimos G   Papatheodoridis George G   Mentis Andreas A   Archimandritis Athanasios A  

Journal of clinical microbiology 20100414 6

Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632). ...[more]

Similar Datasets

Unknown Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan.
| S-EPMC1233989 | biostudies-literature
Unknown Distinct variants of Helicobacter pylori cagA are associated with vacA subtypes.
| S-EPMC85143 | biostudies-literature
Unknown The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori.
| S-EPMC4943970 | biostudies-literature
Unknown VacA promotes CagA accumulation in gastric epithelial cells during Helicobacter pylori infection.
| S-EPMC6328614 | biostudies-literature
Unknown Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases.
| S-EPMC104665 | biostudies-literature
Unknown CagA and VacA polymorphisms do not correlate with severity of histopathological lesions in Helicobacter pylori-infected Greek children.
| S-EPMC2725676 | biostudies-literature
Unknown Relationship between tobacco, cagA and vacA i1 virulence factors and bacterial load in patients infected by Helicobacter pylori.
| S-EPMC4368826 | biostudies-literature
Unknown Association between cagA and vacA genotypes and pathogenesis in a Helicobacter pylori infected population from South-eastern Sweden.
| S-EPMC3520705 | biostudies-literature
Unknown The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated with peptic ulcer and gastric cancer in Mexican population.
| S-EPMC4302603 | biostudies-literature
Unknown Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children.
| S-EPMC3305281 | biostudies-literature