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CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.

ABSTRACT: Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).

SUBMITTER: Panayotopoulou EG

PROVIDER: S-EPMC2884518 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.

Panayotopoulou Effrosini G EG Sgouras Dionyssios N DN Papadakos Konstantinos S KS Petraki Kalliopi K Breurec Sébastien S Michopoulos Spyros S Mantzaris Gerassimos G Papatheodoridis George G Mentis Andreas A Archimandritis Athanasios A

Journal of clinical microbiology 20100414 6

Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632). ...[more]

PMID: 20392907

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