Flux balance analysis accounting for metabolite dilution.
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ABSTRACT:
SUBMITTER: Benyamini T
PROVIDER: S-EPMC2884546 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
Flux balance analysis accounting for metabolite dilution.
Benyamini Tomer T Folger Ori O Ruppin Eytan E Shlomi Tomer T
Genome biology 20100416 4
Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in imp ...[more]
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