Control of Rta expression critically determines transcription of viral and cellular genes following gammaherpesvirus infection.
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ABSTRACT:
SUBMITTER: Hair JR
PROVIDER: S-EPMC2884955 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Publications
Control of Rta expression critically determines transcription of viral and cellular genes following gammaherpesvirus infection.
Hair James R JR Lyons Paul A PA Smith Kenneth G C KGC Efstathiou Stacey S
The Journal of general virology 20070601 Pt 6
The replication and transcriptional activator (Rta), encoded by ORF50 of gammaherpesviruses, initiates the lytic cycle of gene expression; therefore understanding the impact of Rta on viral and cellular gene expression is key to elucidating the transcriptional events governing productive infection and reactivation from latency. To this end, the impact of altering Rta transcription on viral and cellular gene expression was studied in the context of a whole virus infection. Recombinant murine gamm ...[more]
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