Ontology highlight
ABSTRACT:
SUBMITTER: Weyand S
PROVIDER: S-EPMC2885439 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20081016 5902
The nucleobase-cation-symport-1 (NCS1) transporters are essential components of salvage pathways for nucleobases and related metabolites. Here, we report the 2.85-angstrom resolution structure of the NCS1 benzyl-hydantoin transporter, Mhp1, from Microbacterium liquefaciens. Mhp1 contains 12 transmembrane helices, 10 of which are arranged in two inverted repeats of five helices. The structures of the outward-facing open and substrate-bound occluded conformations were solved, showing how the outwa ...[more]