Ontology highlight
ABSTRACT:
SUBMITTER: Faham S
PROVIDER: S-EPMC3654663 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20080703 5890
Membrane transporters that use energy stored in sodium gradients to drive nutrients into cells constitute a major class of proteins. We report the crystal structure of a member of the solute sodium symporters (SSS), the Vibrio parahaemolyticus sodium/galactose symporter (vSGLT). The approximately 3.0 angstrom structure contains 14 transmembrane (TM) helices in an inward-facing conformation with a core structure of inverted repeats of 5 TM helices (TM2 to TM6 and TM7 to TM11). Galactose is bound ...[more]