Ontology highlight
ABSTRACT:
SUBMITTER: Olson BD
PROVIDER: S-EPMC2885577 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Olson Bryan D BD Sgourdou Paraskevi P Downes Gerald B GB
Genesis (New York, N.Y. : 2000) 20100601 6
Zebrafish embryos demonstrate robust swimming behavior, which consists of smooth, alternating body bends. In contrast, several motility mutants have been identified that perform sustained, bilateral trunk muscle contractions which result in abnormal body shortening. Unlike most of these mutants, accordion (acc)(dta5) demonstrates a semidominant effect: Heterozygotes exhibit a distinct but less severe phenotype than homozygotes. Using molecular-genetic mapping and candidate gene analysis, we dete ...[more]