Ontology highlight
ABSTRACT:
SUBMITTER: Lape M
PROVIDER: S-EPMC2885586 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Lape Michael M Elam Christopher C Paula Stefan S
Biophysical chemistry 20100204 1-3
Inhibitors of the transmembrane protein sarco/endoplasmic reticulum calcium ATPase (SERCA) are invaluable tools for the study of the enzyme's physiological functions and they have been recognized as a promising new class of anticancer agents. For the discovery of novel enzyme inhibitors, small molecule docking for virtual screens of large compound libraries has become increasingly important. Since the performance of various docking routines varies considerably, depending on the target and the ch ...[more]