SufA - a bacterial enzyme that cleaves fibrinogen and blocks fibrin network formation.
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ABSTRACT:
SUBMITTER: Karlsson C
PROVIDER: S-EPMC2885652 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
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SufA - a bacterial enzyme that cleaves fibrinogen and blocks fibrin network formation.
Karlsson Christofer C Mörgelin Matthias M Collin Mattias M Lood Rolf R Andersson Marie-Louise ML Schmidtchen Artur A Björck Lars L Frick Inga-Maria IM
Microbiology (Reading, England) 20090101 Pt 1
Finegoldia magna is a member of the normal human bacterial flora on the skin and other non-sterile body surfaces, but this anaerobic coccus is also an important opportunistic pathogen. SufA was the first F. magna proteinase to be isolated and characterized. Many bacterial pathogens interfere with different steps of blood coagulation, and here we describe how purified SufA efficiently and specifically cleaves fibrinogen in human plasma. SufA is both secreted by F. magna and associated with the ba ...[more]
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