A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides.
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ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC18887 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
Publications
A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides.
Yang Z Z Mochalkin I I Doolittle R F RF
Proceedings of the National Academy of Sciences of the United States of America 20001201 26
A blood clot is a meshwork of fibrin fibers built up by the systematic assembly of fibrinogen molecules proteolyzed by thrombin. Here, we describe a model of how the assembly process occurs. Five kinds of interaction are explicitly defined, including two different knob-hole interactions, an end-to-end association between gamma-chains, a lateral association between gamma-chains, and a hypothetical lateral interaction between beta-chains. The last two of these interactions are responsible for prot ...[more]
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