Ontology highlight
ABSTRACT:
SUBMITTER: Owsianka AM
PROVIDER: S-EPMC2885755 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Owsianka Ania M AM Tarr Alexander W AW Keck Zhen-Yong ZY Li Ta-Kai TK Witteveldt Jeroen J Adair Richard R Foung Steven K H SKH Ball Jonathan K JK Patel Arvind H AH
The Journal of general virology 20080301 Pt 3
The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein. Here, we report on their ability to inhibit infection by retroviral pseudoparticles incorporating a panel of full-length E1E2 clones representing the full spectrum of genotypes 1-6. We identified one antibody, CBH-5, that was capable of neutralizing every genotype tested. It also potently inhibited chime ...[more]