Ontology highlight
ABSTRACT:
SUBMITTER: Lee SJ
PROVIDER: S-EPMC2887095 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Lee Seung-Jae SJ Murphy Coleen T CT Kenyon Cynthia C
Cell metabolism 20091101 5
Many studies have addressed the effect of dietary glycemic index on obesity and diabetes, but little is known about its effect on life span itself. We found that adding a small amount of glucose to the medium (2%) shortened the life span of C. elegans by inhibiting the activities of life span-extending transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. This effect involved the downregulation of an aquaporin glycerol ...[more]