Ontology highlight
ABSTRACT:
SUBMITTER: Krishnamurthy P
PROVIDER: S-EPMC2887267 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Krishnamurthy Prasanna P Lambers Erin E Verma Suresh S Thorne Tina T Qin Gangjian G Losordo Douglas W DW Kishore Raj R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100310 7
Prolonged inflammatory response is associated with left ventricular (LV) dysfunction and adverse remodeling following myocardial infarction (MI). IL-10 inhibits inflammation by suppressing HuR-mediated mRNA stabilization of proinflammatory cytokines. Here we report that following MI, IL-10(-/-) mice showed exaggerated LV dysfunction, fibrosis, and cardiomyocyte apoptosis. Short-hairpin RNA (shRNA)-mediated knockdown of HuR in the myocardium significantly reversed MI-induced LV dysfunctions and L ...[more]