Unknown

Dataset Information

0

Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.

ABSTRACT: Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased.

SUBMITTER: Sundstrom-Poromaa I 

PROVIDER: S-EPMC2887346 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.

Sundstrom-Poromaa Inger I   Smith Deborah H DH   Gong Qi Hua QH   Sabado Thomas N TN   Li Xinshe X   Light Adam A   Wiedmann Martin M   Williams Keith K   Smith Sheryl S SS  

Nature neuroscience 20020801 8

Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of de  ...[more]

Similar Datasets

Transcriptomics Artemisinins target GABA receptor signaling to induce alpha to beta cell transdifferentiation
2017-01-19 | GSE84714 | GEO
Unknown Gabapentin increases expression of δ subunit-containing GABA<sub>A</sub> receptors.
| S-EPMC6491385 | biostudies-literature
Unknown Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.
| S-EPMC5016554 | biostudies-literature
Unknown The TM2 6' position of GABA(A) receptors mediates alcohol inhibition.
| S-EPMC3263960 | biostudies-literature
Unknown Nerve growth factor-regulated emergence of functional delta-opioid receptors.
| S-EPMC2865237 | biostudies-literature
Transcriptomics Gene expression changes in alpha GABA receptors in the mice brains after prolonged ketamine administration
2011-01-04 | E-GEOD-26364 | biostudies-arrayexpress
Unknown Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta.
| S-EPMC1806703 | biostudies-other
Unknown A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors.
| S-EPMC5394893 | biostudies-literature
Unknown Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta.
| S-EPMC363122 | biostudies-literature
Unknown Staurosporine, an inhibitor of hormonally up-regulated neu-associated kinase.
| S-EPMC6267597 | biostudies-literature