Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.
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ABSTRACT:
SUBMITTER: Sundstrom-Poromaa I
PROVIDER: S-EPMC2887346 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
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Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.
Sundstrom-Poromaa Inger I Smith Deborah H DH Gong Qi Hua QH Sabado Thomas N TN Li Xinshe X Light Adam A Wiedmann Martin M Williams Keith K Smith Sheryl S SS
Nature neuroscience 20020801 8
Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of de ...[more]
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