Ontology highlight
ABSTRACT:
SUBMITTER: Marjanovic J
PROVIDER: S-EPMC2889071 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Marjanovic Jasmina J Chalupska Dominika D Patenode Caroline C Coster Adam A Arnold Evan E Ye Alice A Anesi George G Lu Ying Y Okun Ilya I Tkachenko Sergey S Haselkorn Robert R Gornicki Piotr P
Proceedings of the National Academy of Sciences of the United States of America 20100503 20
Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism with multiple isozymes often expressed in different eukaryotic cellular compartments. ACC-made malonyl-CoA serves as a precursor for fatty acids; it also regulates fatty acid oxidation and feeding behavior in animals. ACC provides an important target for new drugs to treat human diseases. We have developed an inexpensive nonradioactive high-throughput screening system to identify new ACC inhibitors. The screen uses yeast gene- ...[more]