Ontology highlight
ABSTRACT:
SUBMITTER: McClelland AC
PROVIDER: S-EPMC2889310 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
McClelland Andrew C AC Hruska Martin M Coenen Andrew J AJ Henkemeyer Mark M Dalva Matthew B MB
Proceedings of the National Academy of Sciences of the United States of America 20100421 19
Nervous system function requires tight control over the number of synapses individual neurons receive, but the underlying cellular and molecular mechanisms that regulate synapse number remain obscure. Here we present evidence that a trans-synaptic interaction between EphB2 in the presynaptic compartment and ephrin-B3 in the postsynaptic compartment regulates synapse density and the formation of dendritic spines. Observations in cultured cortical neurons demonstrate that synapse density scales wi ...[more]