Ontology highlight
ABSTRACT:
SUBMITTER: Lie E
PROVIDER: S-EPMC4974644 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Nature communications 20160802
Synaptic adhesion molecules regulate various aspects of synapse development, function and plasticity. These functions mainly involve trans-synaptic interactions and positive regulations, whereas cis-interactions and negative regulation are less understood. Here we report that SALM4, a member of the SALM/Lrfn family of synaptic adhesion molecules, suppresses excitatory synapse development through cis inhibition of SALM3, another SALM family protein with synaptogenic activity. Salm4-mutant (Salm4( ...[more]