Ontology highlight
ABSTRACT:
SUBMITTER: Xie X
PROVIDER: S-EPMC2889336 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Xie Xuefang X Stadnisky Michael D MD Coats Ebony R ER Ahmed Rahim Mir Munir MM Lundgren Alyssa A Xu Wenhao W Makrigiannis Andrew P AP Brown Michael G MG
Proceedings of the National Academy of Sciences of the United States of America 20100426 19
NK cell-mediated murine cytomegalovirus (MCMV) resistance (Cmv(r)) is under H-2(k) control in MA/My mice, but the underlying gene(s) is unclear. Prior genetic analysis mapped Cmv(r) to the MHC class I (MHC-I) D(k) gene interval. Because NK cell receptors are licensed by and responsive to MHC class I molecules, D(k) itself is a candidate gene. A 10-kb genomic D(k) fragment was subcloned and microinjected into MCMV-susceptible (Cmv(s)) (MA/My.L-H2(b) x C57L)F(1) or (B6 x DBA/2)F(2) embryos. Transg ...[more]