Ontology highlight
ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC2193863 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Lee Seung-Hwan SH Zafer Ahmed A de Repentigny Yves Y Kothary Rashmi R Tremblay Michel L ML Gros Philippe P Duplay Pascale P Webb John R JR Vidal Silvia M SM
The Journal of experimental medicine 20030201 4
Natural resistance to infection with mouse cytomegalovirus (MCMV) is controlled by a dominant locus, Cmv1. Cmv1 is linked to the Ly49 family of natural killer receptors on distal chromosome 6. While some studies localized Cmv1 as distal to the Ly49 gene cluster, genetic and functional analysis identified Ly49h as a pivotal factor in resistance to MCMV. The role of these two independent genomic domains in MCMV resistance was evaluated by functional complementation using transgenesis of bacterial ...[more]