Ontology highlight
ABSTRACT:
SUBMITTER: Mokalled MH
PROVIDER: S-EPMC2889604 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Mokalled Mayssa H MH Johnson Aaron A Kim Yuri Y Oh Jiyeon J Olson Eric N EN
Development (Cambridge, England) 20100609 14
Numerous motile cell functions depend on signaling from the cytoskeleton to the nucleus. Myocardin-related transcription factors (MRTFs) translocate to the nucleus in response to actin polymerization and cooperate with serum response factor (Srf) to regulate the expression of genes encoding actin and other components of the cytoskeleton. Here, we show that MRTF-A (Mkl1) and MRTF-B (Mkl2) redundantly control neuronal migration and neurite outgrowth during mouse brain development. Conditional dele ...[more]