Neuronal cadherin (NCAD) increases sensory neurite formation and outgrowth on astrocytes.
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ABSTRACT:
SUBMITTER: Ferguson TA
PROVIDER: S-EPMC3784833 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
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Neuronal cadherin (NCAD) increases sensory neurite formation and outgrowth on astrocytes.
Ferguson Toby A TA Scherer Steven S SS
Neuroscience letters 20120612 2
We examined the neurite outgrowth of sensory neurons on astrocytes following the genetic deletion of N-cadherin (NCAD). Deletion abolished immunostaining for NCAD and the other classical cadherins, indicating that NCAD is likely the only classical cadherin expressed by astrocytes. Only 38% of neurons grown on NCAD-deficient astrocytes for 24 h produced neurites, as compared to 74% of neurons grown on NCAD-expressing astrocytes. Of the neurons that produced neurites, those grown on NCAD-deficient ...[more]
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