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Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta.


ABSTRACT: Three new sulfated sterol dimers, fibrosterol sulfates A-C (1-3), have been isolated from the sponge Lissodendoryx (Acanthodoryx) fibrosa, collected in the Philippines. The structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1 and 2 inhibited PKCzeta with IC(50) values of 16.4 and 5.6 microM, respectively.

SUBMITTER: Whitson EL 

PROVIDER: S-EPMC2889921 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta.

Whitson Emily L EL   Bugni Tim S TS   Chockalingam Priya S PS   Concepcion Gisela P GP   Feng Xidong X   Jin Guixian G   Harper Mary Kay MK   Mangalindan Gina C GC   McDonald Leonard A LA   Ireland Chris M CM  

The Journal of organic chemistry 20090801 16


Three new sulfated sterol dimers, fibrosterol sulfates A-C (1-3), have been isolated from the sponge Lissodendoryx (Acanthodoryx) fibrosa, collected in the Philippines. The structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1 and 2 inhibited PKCzeta with IC(50) values of 16.4 and 5.6 microM, respectively. ...[more]

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