Ontology highlight
ABSTRACT:
SUBMITTER: Anderson TM
PROVIDER: S-EPMC3992202 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Anderson Thomas M TM Clay Mary C MC Cioffi Alexander G AG Diaz Katrina A KA Hisao Grant S GS Tuttle Marcus D MD Nieuwkoop Andrew J AJ Comellas Gemma G Maryum Nashrah N Wang Shu S Uno Brice E BE Wildeman Erin L EL Gonen Tamir T Rienstra Chad M CM Burke Martin D MD
Nature chemical biology 20140330 5
For over 50 years, amphotericin has remained the powerful but highly toxic last line of defense in treating life-threatening fungal infections in humans with minimal development of microbial resistance. Understanding how this small molecule kills yeast is thus critical for guiding development of derivatives with an improved therapeutic index and other resistance-refractory antimicrobial agents. In the widely accepted ion channel model for its mechanism of cytocidal action, amphotericin forms agg ...[more]