Dataset Information

Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance.

ABSTRACT:

Objective

To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance.

Research design and methods

In 1,176 South Asian, Chinese, Aboriginal, and European Canadians, fasting blood samples were drawn, and clinical history and dietary habits including glycemic index/glycemic load were recorded using standardized questionnaires. Insulin resistance was defined using homeostasis model assessment-insulin resistance (HOMA-IR).

Results

Adiponectin concentrations were significantly higher in Europeans (adjusted mean 12.94 [95% CI 2.27-13.64]) and Aboriginal people (11.87 [11.19-12.59]) than in South Asians (9.35 [8.82-9.92]) and Chinese (8.52 [8.03-9.03]) (overall P < 0.001). Serum leptin was significantly higher in South Asians (11.82 [10.72-13.04]) and Aboriginal people (11.13 [10.13-12.23]) than in Europeans (9.21 [8.38-10.12]) and Chinese (8.25 [7.48-9.10]). BMI and waist circumference were inversely associated with adiponectin in every group except the South Asians (P < 0.001 for interaction). Adiponectin was inversely and leptin was positively associated with HOMA-IR (P < 0.001). The increase in HOMA-IR for each given decrease in adiponectin was larger among South Asians (P = 0.01) and Aboriginal people (P < 0.001) than among Europeans. A high glycemic index was associated with a larger decrease in adiponectin among South Asians (P = 0.03) and Aboriginal people (P < 0.001) and a larger increase in HOMA-IR among South Asians (P < 0.05) relative to that in other groups.

Conclusions

South Asians have the least favorable adipokine profile and, like the Aboriginal people, display a greater increase in insulin resistance with decreasing levels of adiponectin. Differences in adipokines and responses to glycemic foods parallel the ethnic differences in insulin resistance.

SUBMITTER: Mente A

PROVIDER: S-EPMC2890372 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Publications

Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance.

Mente Andrew A Razak Fahad F Blankenberg Stefan S Vuksan Vlad V Davis A Darlene AD Miller Ruby R Teo Koon K Gerstein Hertzel H Sharma Arya M AM Yusuf Salim S Anand Sonia S SS

Diabetes care 20100422 7

<h4>Objective</h4>To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance.<h4>Research design and methods</h4>In 1,176 South Asian, Chinese, Aboriginal, and European Canadians, fasting blood samples were drawn, and clinical history and dietary habits including glycemic index/glycemic load were recorded using standardized questionnaires. Insulin resistance ...[more]

PMID: 20413520

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Dataset Information

Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance.

Objective

Research design and methods

Results

Conclusions

Publications

Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance.

Similar Datasets

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