Peptide antagonism as a mechanism for NK cell activation.
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ABSTRACT:
SUBMITTER: Fadda L
PROVIDER: S-EPMC2890497 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Peptide antagonism as a mechanism for NK cell activation.
Fadda Lena L Borhis Gwenoline G Ahmed Parvin P Cheent Kuldeep K Pageon Sophie V SV Cazaly Angelica A Stathopoulos Stavros S Middleton Derek D Mulder Arend A Claas Frans H J FH Elliott Tim T Davis Daniel M DM Purbhoo Marco A MA Khakoo Salim I SI
Proceedings of the National Academy of Sciences of the United States of America 20100503 22
Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC cla ...[more]
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