Ontology highlight
ABSTRACT:
SUBMITTER: Borhis G
PROVIDER: S-EPMC3672982 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Borhis Gwenoline G Ahmed Parvin S PS Mbiribindi Bérénice B Naiyer Mohammed M MM Davis Daniel M DM Purbhoo Marco A MA Khakoo Salim I SI
Journal of immunology (Baltimore, Md. : 1950) 20130204 6
Productive engagement of MHC class I by inhibitory NK cell receptors depends on the peptide bound by the MHC class I molecule. Peptide:MHC complexes that bind weakly to killer cell Ig-like receptors (KIRs) can antagonize the inhibition mediated by high-affinity peptide:MHC complexes and cause NK cell activation. We show that low-affinity peptide:MHC complexes stall inhibitory signaling at the step of Src homology protein tyrosine phosphatase 1 recruitment and do not go on to form the KIR microcl ...[more]