Ontology highlight
ABSTRACT:
SUBMITTER: Zhang QC
PROVIDER: S-EPMC2890749 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Zhang Qiangfeng Cliff QC Petrey Donald D Norel Raquel R Honig Barry H BH
Proceedings of the National Academy of Sciences of the United States of America 20100601 24
With the advent of Systems Biology, the prediction of whether two proteins form a complex has become a problem of increased importance. A variety of experimental techniques have been applied to the problem, but three-dimensional structural information has not been widely exploited. Here we explore the range of applicability of such information by analyzing the extent to which the location of binding sites on protein surfaces is conserved among structural neighbors. We find, as expected, that int ...[more]