Discrete-continuous duality of protein structure space.
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ABSTRACT:
SUBMITTER: Sadreyev RI
PROVIDER: S-EPMC3688466 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Discrete-continuous duality of protein structure space.
Sadreyev Ruslan I RI Kim Bong-Hyun BH Grishin Nick V NV
Current opinion in structural biology 20090529 3
Recently, the nature of protein structure space has been widely discussed in the literature. The traditional discrete view of protein universe as a set of separate folds has been criticized in the light of growing evidence that almost any arrangement of secondary structures is possible and the whole protein space can be traversed through a path of similar structures. Here we argue that the discrete and continuous descriptions are not mutually exclusive, but complementary: the space is largely di ...[more]
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