Mixed T cell receptor dimers harbor potentially harmful neoreactivity.
Ontology highlight
ABSTRACT:
SUBMITTER: van Loenen MM
PROVIDER: S-EPMC2890759 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Mixed T cell receptor dimers harbor potentially harmful neoreactivity.
van Loenen Marleen M MM de Boer Renate R Amir Avital L AL Hagedoorn Renate S RS Volbeda Gerdien L GL Willemze Roelof R van Rood Johannes J JJ Falkenburg J H Frederik JH Heemskerk Mirjam H M MH
Proceedings of the National Academy of Sciences of the United States of America 20100601 24
Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to target both hematological malignancies and solid tumors. By introducing a TCR, large numbers of T cells with defined antigen (Ag) specificity can be obtained. However, by introduction of a TCR, mixed TCR dimers can be formed. Besides the decrease in TCR expression of the introduced and endogenous TCR, these mixed TCR dimers could harbor potentially harmful specificities. In this study, we demonstrate t ...[more]
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