Ontology highlight
ABSTRACT:
SUBMITTER: Bosco A
PROVIDER: S-EPMC2891355 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Bosco A A Ehteshami S S Stern D A DA Martinez F D FD
Mucosal immunology 20100324 4
Asthma exacerbations are associated with subsequent deficits in lung function. Here, we tested the hypothesis that a specific pattern of inflammatory responses during acute exacerbations may be associated with chronic airway obstruction. Gene coexpression networks were characterized in induced sputum obtained during an acute exacerbation, from asthmatic children with or without chronic airflow limitation. The data showed that activation of Th1-like/cytotoxic and interferon signaling pathways dur ...[more]