Ontology highlight
ABSTRACT:
SUBMITTER: Desai S
PROVIDER: S-EPMC2891394 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Desai Shruti S Maurin Michelle M Smith Matthew A MA Bolick Sophia C E SC Dessureault Sophie S Tao Jianguo J Sotomayor Eduardo E Wright Kenneth L KL
Molecular cancer research : MCR 20100608 6
Mantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma with a poor disease-free survival rate. The proteasome inhibitor bortezomib is approved for the treatment of relapsed and refractory MCL and has efficacy in about 30% of patients. However, the precise mechanism of action of bortezomib is not well understood. This report establishes a requirement for the transcription repressor PR domain zinc finger protein 1 (PRDM1, Blimp1) in the response to bortezomib. Bortezomib rapidly induc ...[more]