Proteomics

Dataset Information

0

Proteaphagy contributes to bortezomib resistance in mantle cell lymphoma


ABSTRACT: TUBE and GST enrichment followed by 1D-gel-LC-MS analysis on cell exract from bortezomib (BTZ)-resistant or sensitive mantle cell lymphoma cells.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Lymphoma

SUBMITTER: Rune Matthiesen  

LAB HEAD: Manuel S. Rodriguez [1]/Rune Matthiesen [2]

PROVIDER: PXD011867 | Pride | 2022-02-28

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
PepMod.txt Txt
ProMod.txt Txt
R4_Z138_GST_1.RAW Raw
R4_Z138_GST_1.txt Txt
R4_Z138_GST_10.RAW Raw
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Publications


Protein ubiquitylation coordinates crucial cellular events in physiological and pathological conditions. A comparative analysis of the ubiquitin proteome from bortezomib (BTZ)-sensitive and BTZ-resistant mantle cell lymphoma (MCL) revealed an enrichment of the autophagy-lysosome system (ALS) in BTZ-resistant cells. Pharmacological inhibition of autophagy at the level of lysosome-fusion revealed a constitutive activation of proteaphagy and accumulation of proteasome subunits within autophagosomes  ...[more]

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