Ontology highlight
ABSTRACT:
SUBMITTER: Haberman RP
PROVIDER: S-EPMC2891610 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Haberman Rebecca P RP Colantuoni Carlo C Stocker Amy M AM Schmidt Alexandra C AC Pedersen Jan T JT Gallagher Michela M
Neurobiology of aging 20091113 9
Research in aging laboratory animals has characterized physiological and cellular alterations in medial temporal lobe structures, particularly the hippocampus, that are central to age-related memory deficits. The current study compares molecular alterations across hippocampal subregions in a rat model that closely mirrors individual differences in neurocognitive features of aging humans, including both impaired memory and preserved function. Using mRNA profiling of the CA1, CA3 and dentate gyrus ...[more]