Ontology highlight
ABSTRACT:
SUBMITTER: Eilebrecht S
PROVIDER: S-EPMC2892505 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Eilebrecht Sebastian S Smet-Nocca Caroline C Wieruszeski Jean-Michel JM Benecke Arndt A
BMC research notes 20100526 1
<h4>Background</h4>Conjugation of small ubiquitin-related modifiers (SUMOs) is a frequent post-translational modification of proteins. SUMOs can also temporally associate with protein-targets via SUMO binding motifs (SBMs). Protein sumoylation has been identified as an important regulatory mechanism especially in the regulation of transcription and the maintenance of genome stability. The precise molecular mechanisms by which SUMO conjugation and association act are, however, not understood.<h4> ...[more]