Ontology highlight
ABSTRACT:
SUBMITTER: Schuermann JP
PROVIDER: S-EPMC2892728 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20080612 2
Hsp70s mediate protein folding, translocation, and macromolecular complex remodeling reactions. Their activities are regulated by proteins that exchange ADP for ATP from the nucleotide-binding domain (NBD) of the Hsp70. These nucleotide exchange factors (NEFs) include the Hsp110s, which are themselves members of the Hsp70 family. We report the structure of an Hsp110:Hsc70 nucleotide exchange complex. The complex is characterized by extensive protein:protein interactions and symmetric bridging in ...[more]