Ontology highlight
ABSTRACT:
SUBMITTER: Bernardini MQ
PROVIDER: S-EPMC2893110 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Bernardini Marcus Q MQ Baba Tsukasa T Lee Paula S PS Barnett Jason C JC Sfakianos Gregory P GP Secord Angeles Alvarez AA Murphy Susan K SK Iversen Edwin E Marks Jeffrey R JR Berchuck Andrew A
BMC cancer 20100526
<h4>Background</h4>Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology and biology of the disease.<h4>Methods</h4>The TP53 coding region was sequenced in 89 frozen serous ovarian cancers, 40 early stage (I/II) and 49 advanced stage (III/IV). Affymetrix U133A expression data was used to define gene expression patterns by mutation, type of m ...[more]