Utahmycins a and B, azaquinones produced by an environmental DNA clone.
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ABSTRACT:
SUBMITTER: Bauer JD
PROVIDER: S-EPMC2893554 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Utahmycins a and B, azaquinones produced by an environmental DNA clone.
Bauer John D JD King Ryan W RW Brady Sean F SF
Journal of natural products 20100501 5
Two new azaquinones, utahmycins A (1) and B (2), were isolated from cultures of Streptomyces albus J1704 transformed with the environmental DNA-derived Erd gene cluster. The structures of 1 and 2 were elucidated by spectroscopic analyses. The structure of 1 was confirmed by single-crystal X-ray diffraction analysis. Both metabolites appear to arise from the addition of a nitrogen atom to erdacin biosynthetic intermediates. Utahmycin A (1) is the first example of a biologically derived 1,3-dimeth ...[more]
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