Ontology highlight
ABSTRACT:
SUBMITTER: Prasad R
PROVIDER: S-EPMC2893977 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20100512 13
Intracellular quality control systems monitor protein conformational states. Irreversibly misfolded proteins are cleared through specialized degradation pathways. Their importance is underscored by numerous pathologies caused by aberrant proteins. In the cytosol, where most proteins are synthesized, quality control remains poorly understood. Stress-inducible chaperones and the 26S proteasome are known mediators but how their activities are linked is unclear. To better understand these mechanisms ...[more]