Ontology highlight
ABSTRACT:
SUBMITTER: VanHouten J
PROVIDER: S-EPMC2895115 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
VanHouten Joshua J Sullivan Catherine C Bazinet Caroline C Ryoo Tom T Camp Robert R Rimm David L DL Chung Gina G Wysolmerski John J
Proceedings of the National Academy of Sciences of the United States of America 20100604 25
After lactation, weaning causes mammary epithelial cell (MEC) apoptosis. MECs express the plasma membrane calcium-ATPase 2 (PMCA2), which transports calcium across the apical surface of the cells into milk. Here we show that PMCA2 is down-regulated early in mammary involution associated with changes in MEC shape. We demonstrate that loss of PMCA2 expression raises intracellular calcium levels and sensitizes MECs to apoptosis. In contrast, overexpression of PMCA2 in T47D breast cancer cells lower ...[more]