Unknown

Dataset Information

0

Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.


ABSTRACT: Dendritic cells (DCs) play a central role in determining the induction of T cell responses. IL-27 production by DCs favors induction of IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell responses. The regulatory mechanisms in DCs that control these two cells types are not understood well. Here, we show that IFN-gamma induces IL-27 while inhibiting OPN expression in DCs both in vitro and in vivo and that engagement of IFN-gammaR expressed by DCs leads to suppression of IL-17 production while inducing IL-10 from T cells. DCs modified by IFN-gamma acquire IL-27-dependent regulatory function, promote IL-10-mediated T cell tolerance, and suppress autoimmune inflammation. Thus, our results identify a previously unknown pathway by which IFN-gamma limits IL-17-mediated autoimmune inflammation through differential regulation of OPN and IL-27 expression in DCs.

SUBMITTER: Murugaiyan G 

PROVIDER: S-EPMC2895126 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.

Murugaiyan Gopal G   Mittal Akanksha A   Weiner Howard L HL  

Proceedings of the National Academy of Sciences of the United States of America 20100607 25


Dendritic cells (DCs) play a central role in determining the induction of T cell responses. IL-27 production by DCs favors induction of IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell responses. The regulatory mechanisms in DCs that control these two cells types are not understood well. Here, we show that IFN-gamma induces IL-27 while inhibiting OPN expression in DCs both in vitro and in vivo and that engagement of IFN-gammaR expressed by DCs leads  ...[more]

Similar Datasets

| S-EPMC3504131 | biostudies-literature
| S-EPMC4577839 | biostudies-literature
| S-EPMC6828851 | biostudies-literature
| S-EPMC7751976 | biostudies-literature
| S-EPMC6857067 | biostudies-literature
| S-EPMC10608798 | biostudies-literature
| S-EPMC5398558 | biostudies-literature
| S-EPMC9359210 | biostudies-literature
| S-EPMC9479610 | biostudies-literature
| S-EPMC7879974 | biostudies-literature