Ontology highlight
ABSTRACT:
SUBMITTER: Yin L
PROVIDER: S-EPMC2895127 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Yin Lei L Joshi Shree S Wu Nan N Tong Xin X Lazar Mitchell A MA
Proceedings of the National Academy of Sciences of the United States of America 20100607 25
The metazoan circadian clock mechanism involves cyclic transcriptional activation and repression by proteins whose degradation is highly regulated via the ubiquitin-proteasome pathway. The heme receptor Rev-erb alpha, a core negative component of the circadian network, controls circadian oscillation of several clock genes, including Bmal1 Rev-erb alpha protein degradation can be triggered by inhibitors of glycogen synthase kinase 3beta, such as lithium, and also by serum shock, which synchronize ...[more]