Ontology highlight
ABSTRACT:
SUBMITTER: Seregin SS
PROVIDER: S-EPMC3177950 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Seregin Sergey S SS Aldhamen Yasser A YA Appledorn Daniel M DM Zehnder Jennifer J Voss Tyler T Godbehere Sarah S Amalfitano Andrea A
Human gene therapy 20110418 9
Adenovirus (Ad)-based vectors are attractive candidates for a variety of gene-transfer applications. In this study, we found that decay-accelerating factor (DAF)-displaying Ads induce significantly decreased cellular immune responses to transgenes expressed from the vectors in both Ad5-naive and Ad5-immune mice. Specifically, we found a diminished ability of splenocytes to secrete interferon-γ after recall exposure to multiple peptides derived from antigens expressed by DAF-displaying Ads. We al ...[more]