Ontology highlight
ABSTRACT:
SUBMITTER: Dong Y
PROVIDER: S-EPMC2895818 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Dong Yimin Y Vanden Beldt Kristin J KJ Meng Xing X Khodjakov Alexey A McEwen Bruce F BF
Nature cell biology 20070415 5
Intricate interactions between kinetochores and microtubules are essential for the proper distribution of chromosomes during mitosis. A crucial long-standing question is how vertebrate kinetochores generate chromosome motion while maintaining attachments to the dynamic plus ends of the multiple kinetochore MTs (kMTs) in a kinetochore fibre. Here, we demonstrate that individual kMTs in PtK(1) cells are attached to the kinetochore outer plate by several fibres that either embed the microtubule plu ...[more]