Ontology highlight
ABSTRACT:
SUBMITTER: Gonen S
PROVIDER: S-EPMC3443262 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Gonen Shane S Akiyoshi Bungo B Iadanza Matthew G MG Shi Dan D Duggan Nicole N Biggins Sue S Gonen Tamir T
Nature structural & molecular biology 20120812 9
Chromosomes must be accurately partitioned to daughter cells to prevent aneuploidy, a hallmark of many tumors and birth defects. Kinetochores are the macromolecular machines that segregate chromosomes by maintaining load-bearing attachments to the dynamic tips of microtubules. Here, we present the structure of isolated budding-yeast kinetochore particles, as visualized by EM and electron tomography of negatively stained preparations. The kinetochore appears as an ~126-nm particle containing a la ...[more]