Ontology highlight
ABSTRACT:
SUBMITTER: Domian IJ
PROVIDER: S-EPMC2895998 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Domian Ibrahim J IJ Chiravuri Murali M van der Meer Peter P Feinberg Adam W AW Shi Xi X Shao Ying Y Wu Sean M SM Parker Kevin Kit KK Chien Kenneth R KR
Science (New York, N.Y.) 20091001 5951
The mammalian heart is formed from distinct sets of first and second heart field (FHF and SHF, respectively) progenitors. Although multipotent progenitors have previously been shown to give rise to cardiomyocytes, smooth muscle, and endothelial cells, the mechanism governing the generation of large numbers of differentiated progeny remains poorly understood. We have employed a two-colored fluorescent reporter system to isolate FHF and SHF progenitors from developing mouse embryos and embryonic s ...[more]