Ontology highlight
ABSTRACT:
SUBMITTER: Bachrach E
PROVIDER: S-EPMC373505 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Bachrach Estanislao E Li Sheng S Perez Antonio L AL Schienda Jaclyn J Liadaki Kalliopi K Volinski Jay J Flint Alan A Chamberlain Jeffrey J Kunkel Louis M LM
Proceedings of the National Academy of Sciences of the United States of America 20040301 10
Cell-based therapy for Duchenne muscular dystrophy patients and mdx mice has proven to be a safe but ineffective form of treatment. Recently, a group of cells called muscle side population (SP) cells have been isolated based on their ability to efflux the DNA-binding dye Hoechst. To understand the potential of skeletal muscle SP cells to serve as precursors for muscle, SP cells from the two mice strains mdx(5cv) and C57BL/6N were isolated, transduced, and transplanted. Under coculture conditions ...[more]