The crystal structure of unmodified tRNAPhe from Escherichia coli.
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ABSTRACT:
SUBMITTER: Byrne RT
PROVIDER: S-EPMC2896525 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
The crystal structure of unmodified tRNAPhe from Escherichia coli.
Byrne Robert T RT Konevega Andrey L AL Rodnina Marina V MV Antson Alfred A AA
Nucleic acids research 20100304 12
Post-transcriptional nucleoside modifications fine-tune the biophysical and biochemical properties of transfer RNA (tRNA) so that it is optimized for participation in cellular processes. Here we report the crystal structure of unmodified tRNA(Phe) from Escherichia coli at a resolution of 3 A. We show that in the absence of modifications the overall fold of the tRNA is essentially the same as that of mature tRNA. However, there are a number of significant structural differences, such as rearrange ...[more]
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